I have long supported the idea of keeping your feet dry and well-cushioned when you're beginning a new exercise regime, increasing your running mileage, or increasing your running tempo, to prevent blisters. I tell my athletes to wear 2 pair of socks so the friction occurs between the socks and not between the skin and your socks. I love using Spenco's 2nd Skin to reduce friction over "hot spots." But I have to share a new product with you specifically for the toes called Pro-Tec Toe Caps. It does two important jobs: prevents blisters on the toes and protects against toenail loss.
What I like best about these is that there's no need for a band-aid or tape to hold the product on. This reduces the bulk in the toebox of your shoe as well as reduces the friction these can cause against neighboring toes.
I haven't tried this product yet, but let me know if you do and give me some feedback about the pros and cons of it.